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RESEARCH ARTICLE
Year : 2019  |  Volume : 4  |  Issue : 3  |  Page : 87-90

Clinical significance of electrocardiograph abnormalities: Analysis on electrocardiographs of 75 Marfan cases complicated with aortic disease


1 Department of Cardiology, Deltahealth Hospital, Shanghai, China
2 Department of Cardiology, Deltahealth Hospital; Department of Cardiology, Zhongshan Hospital, Fudan University; Shanghai Institute of Cardiovascular Diseases, Shanghai, China
3 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China

Correspondence Address:
Zhenning Nie
Department of Cardiology, Zhongshan Hospital, NO.180, Fenglin Road, Shanghai, 200032
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/cp.cp_8_19

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Purpose: Marfan syndrome (MFS) is one of the most common hereditary connective tissue disorders, with various adverse manifestations ranging from typical ocular, cardiovascular, and musculoskeletal abnormalities to manifestations involving the lungs, skin, and central nervous system. In patients with MFS, the most lethal manifestations are aortic lesion presenting as aortic insufficiency, thoracic and abdominal aortic dilatation, aneurysm, and dissection. Clinically, these patients often present with various types of arrhythmias and abnormal electrocardiographs (EKGs); however, there have been few studies of MFS-associated arrhythmias either in China or abroad. This investigation aims to elucidate the association between Marfan-associated aortic lesions and accompanying arrhythmia characteristics. Methods: From September 2016 to January 2018, 75 consecutive patients diagnosed with MFS and aortic disease manifestation were enrolled in the study (MFS group). During the same time period, 76 consecutive nonMFS patients with aortic disease were enrolled as positive controls (dissection group) and 100 consecutive healthy patients were enrolled during routine health checkups as negative controls (checkup group). EKG characteristics between the three groups were analyzed. Results: Compared to the checkup group, both the MFS group and dissection group showed more EKG abnormalities (P < 0.01). Even though there was no significant difference in the incidence of EKG abnormalities between the MFS group and the dissection group (P > 0.05), the MFS group showed a significantly higher occurrence of sinus bradycardia and first-degree atrioventricular block (P < 0.05) compared to the dissection group. Furthermore, the MFS group showed a significantly higher occurrence of left ventricular high voltage with accompanying ST-T change (P < 0.01) compared to the dissection group. Finally, the MFS group showed a significantly higher occurrence of left atrial abnormality (P < 0.05) compared to the dissection group. Conclusion: Patients with MFS and aortic disease manifestation have unique EKG abnormality characteristics. This may be associated with the connective tissue disease affecting the physiological electric conduction in the heart and long-term volume overload leading to myocardial damage.


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