REVIEW ARTICLE
Year : 2021  |  Volume : 6  |  Issue : 1  |  Page : 41-47

Gut microbiota, metabolites, and cardiovascular diseases


1 Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education; Key Laboratory of Molecular Cardiology, Xi'an, Shaanxi Province, China
2 Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi Province, China
3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education; Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province, China

Correspondence Address:
Lu Ma
Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi Province
China
Yue Wu
Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xifan 710061, Shaanxi Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2470-7511.312593

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Numerous studies unveiled the interactions between intestinal flora and the host and how these affect human health and disease. The gut microbiota and its metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids, and secondary bile acids, are related to human metabolism, immunity, and diseases. An increasing number of studies has indicated that intestinal flora and its metabolites contribute to cardiovascular diseases (CVDs) development. Revealing the role of intestinal flora and its metabolites in cardiovascular pathogenesis may provide novel strategies for preventing and treating CVDs. However, the specific mechanisms are unclear, and more research is warranted. Here, we reviewed the most recent research progress on the relationship between intestinal flora, its metabolites, and CVDs.


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