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  Indian J Med Microbiol
 

Figure 2: ApoA-I-binding protein-mediated targeted cholesterol efflux from endothelial cells disrupts lipid rafts/caveolae and suppresses vascular endothelial growth factor receptor 2 signaling. Vascular endothelial growth factor-A-induced vascular endothelial growth factor receptor 2 signaling induces the receptor dimerization in cholesterol-rich caveolae. ApoA-I-binding protein-mediated cholesterol removal disrupts lipid rafts/caveolae, which impairs vascular endothelial growth factor receptor 2 signaling and limits angiogenesis

Figure 2: ApoA-I-binding protein-mediated targeted cholesterol efflux from endothelial cells disrupts lipid rafts/caveolae and suppresses vascular endothelial growth factor receptor 2 signaling. Vascular endothelial growth factor-A-induced vascular endothelial growth factor receptor 2 signaling induces the receptor dimerization in cholesterol-rich caveolae. ApoA-I-binding protein-mediated cholesterol removal disrupts lipid rafts/caveolae, which impairs vascular endothelial growth factor receptor 2 signaling and limits angiogenesis