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  Indian J Med Microbiol
 

Figure 1: Clinical pathway of lipid management in patients with ACS with high-risk factors: (1) If the patients are intolerant to statins, the use of nonstatin lipid-lowering drugs directly is recommended. (2) Based on the evidence in recent patients with ACS, priority is given to the use of alirocumab. (3) In order to avoid the rebound of the lipid-lowering effect, consider drug withdrawal according to the range of each drug to reduce LDL-C. (4) After combined lipid-lowering drug treatment, LDL-C level has not reached the target level, especially if the disease is in progress. In addition, we suggest that the use of lipoprotein plasma exchange as an adjuvant therapy should be considered.[36] Note: ACS: Acute coronary syndrome, LDL-C: Low-density lipoprotein-cholesterol, PCSK9: Proprotein-converting enzyme subtilisin 9

Figure 1: Clinical pathway of lipid management in patients with ACS with high-risk factors: (1) If the patients are intolerant to statins, the use of nonstatin lipid-lowering drugs directly is recommended. (2) Based on the evidence in recent patients with ACS, priority is given to the use of alirocumab. (3) In order to avoid the rebound of the lipid-lowering effect, consider drug withdrawal according to the range of each drug to reduce LDL-C. (4) After combined lipid-lowering drug treatment, LDL-C level has not reached the target level, especially if the disease is in progress. In addition, we suggest that the use of lipoprotein plasma exchange as an adjuvant therapy should be considered.<sup>[36]</sup> Note: ACS: Acute coronary syndrome, LDL-C: Low-density lipoprotein-cholesterol, PCSK9: Proprotein-converting enzyme subtilisin 9