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  Indian J Med Microbiol
 

Figure 6: Changes in the mRNA levels of key enzymes involved in glucose and lipid metabolism in the different groups. A-C, Relative mRNA levels of enzymes involved in glucose metabolism including (A) GLUT4, (B) GLUT1, and (C) PDK4. Elevated GLUT4 and PDK4 indicate increased glucose absorption with suppressed glucose oxidation in TAC + 2 group. D-H, Relative mRNA levels of enzymes involved in fatty acid oxidation including (D) CPT-1α, (E) CRAT, (F) CROT, (G) ACOT1, and (H) ACOT2. Expression of CRAT, ACOT1, and ACOT2 were augmented in the dapagliflozin (dapa) treatment groups relative to the TAC group, suggesting upregulation of medium-chain fatty acid oxidation. *P < 0.05, **P < 0.01,***P<0.001 vs. the sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the TAC group, Student's t-test. Results are expressed as the mean ± SD. GLU4: Glucose transporter 4, dapa: Dapagliflozin, TAC: Thoracic aortic constriction, GLUT1: Glucose transporter 1, PDK4: Pyruvate dehydrogenase lipoamide kinase isozyme 4, CPT-1α: Carnitine palmitoyltransferase-1α, CRAT: Carnitine O-acetyltransferase,CROT: Carnitine O-octanoyltransferase, ACOT1: Acyl-CoA thioesterase 1, SD: Standard deviation

Figure 6: <b>Changes in the mRNA levels of key enzymes involved in glucose and lipid metabolism in the different groups.</b>
<b>A-C</b>, Relative mRNA levels of enzymes involved in glucose metabolism including (<b>A</b>) GLUT4, (<b>B</b>) GLUT1, and (<b>C</b>) PDK4. Elevated GLUT4 and PDK4 indicate increased glucose absorption with suppressed glucose oxidation in TAC + 2 group. D-H, Relative mRNA levels of enzymes involved in fatty acid oxidation including (<b>D</b>) CPT-1α, (<b>E</b>) CRAT, (F) CROT, (<b>G</b>) ACOT1, and (<b>H</b>) ACOT2. Expression of CRAT, ACOT1, and ACOT2 were augmented in the dapagliflozin (dapa) treatment groups relative to the TAC group, suggesting upregulation of medium-chain fatty acid oxidation.
*<i>P</i> < 0.05, **<i>P</i> < 0.01,***<i>P</i><0.001 vs. the sham group; #<i>P</i> < 0.05, ##<i>P</i> < 0.01, ###<i>P</i> < 0.001 vs. the TAC group, Student's <i>t</i>-test. Results are expressed as the mean ± SD.
GLU4: Glucose transporter 4, dapa: Dapagliflozin, TAC: Thoracic aortic constriction, GLUT1: Glucose transporter 1, PDK4: Pyruvate dehydrogenase lipoamide kinase isozyme 4, CPT-1α: Carnitine palmitoyltransferase-1α, CRAT: Carnitine O-acetyltransferase,CROT: Carnitine O-octanoyltransferase, ACOT1: Acyl-CoA thioesterase 1, SD: Standard deviation